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They are most beneficial for people with poor B12 absorption, including those with pernicious anemia, gastric surgery, long-term metformin use, or age-related changes in the gut

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The functionally active form of thiamine is thiamine pyrophosphate which is involved in the metabolism of carbohydrates as dehydrogenases factor (ketoacidotic branched chain dehydrogenase complex piruvatodeshidrogenasa or alpha-ketoglutarate dehydrogenase) and transcetolasas